Adjuvanticity of an Ornithine-Containing Lipid ofFlavobacterium meningosepticumas a Candidate Vaccine Adjuvant
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چکیده
منابع مشابه
Potentiation of human papilloma vaccine candidate using naloxone/alum mixture as an adjuvant: increasing immunogenicity of HPV-16E7d vaccine
Objective(s): Many types of human papillomaviruses (HPVs) have been identified, with some leading to cancer and others to skin lesions such as anogenital warts. Studies have demonstrated an association between oncogenic HPV and cervical cancer and many researchers have focused on therapeutic vaccines development. At present, the modulatory effect of opioids on the innate and acquired immune sys...
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alpha-N-(3-Acyloxyacyl)-ornithine (or -serine) is the structure of lipoamino acids obtained by us previously from some gram-negative bacteria (Y. Kawai and I. Yano, Eur. J. Biochem. 136:531-538, 1983; Y. Kawai, I. Yano, and K. Kaneda, Eur. J. Biochem. 171:73-80, 1988; Y. Kawai, I. Yano, K. Kaneda, and E. Yabuuchi, Eur. J. Biochem. 175:633-641, 1988). The 3-acyloxyacylamide structure is present ...
متن کاملThe structure of an ornithine-containing lipid from Thiobacillus thiooxidans.
The structure of an ornithine-containing lipid from Z’Gobacillus fhiooxidans has been elucidated. Methanolysis of the lipid released methyl cis-ll,lZ-methylene-Z-hydroxyoctadecanoate. Acid hydrolysis of the residue yielded ornithine and a mixture of fatty acids, the major components of which were 3-hydroxyhexadecanoic and 2-hexadecenoic acids. Identification of the 3-hydroxy fatty acid was base...
متن کاملProtection of mice from lethal endotoxemia by use of an ornithine-containing lipid or a serine-containing lipid.
The effects of an ornithine-containing lipid [alpha-N-(3-acyloxyacyl)-ornithine (Orn-L)] or a serine-containing lipid [alpha-N-(3-acyloxyacyl)-serine (Ser-L)] from Flavobacterium meningosepticum on lethal endotoxemia in mice were examined. When 500 micrograms of Orn-L was intravenously administered 1 h before intravenous administration of a lethal dose of endotoxin, none of the mice died. The p...
متن کاملRNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine
Nasal vaccination has the potential to elicit systemic and mucosal immunity against pathogens. However, split and subunit vaccines lack potency at stimulating mucosal immunity, and an adjuvant is indispensable for eliciting potent mucosal immune response to nasal vaccines. Endocine, a lipid-based mucosal adjuvant, potentiates both systemic and mucosal immune responses. Although Endocine has sho...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1997
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1997.tb01175.x